Drug Standards
Apexbio Technology LLC AP20187 195514-80-8 50mg
AP20187 (CAS 195514-80-8) is a small molecule dimerizer commonly employed as a chemical inducer of dimerization (CID) in conditional gene expression systems Upon administration AP20187 promotes controlled protein-protein interactions by inducing engineered fusion proteins to dimerize enabling selective activation of signaling pathways In vivo studies demonstrate that AP20187-mediated CID enhances the proliferation of transduced erythrocytes platelets and to a lesser extent granulocytes Additionally AP20187 is utilized in AP20187 LFv2IRE systems activating chimeric insulin receptors which subsequently increases hepatic glycogen levels and promotes glucose uptake in skeletal muscle Such regulated activation systems have significant potential in gene therapy and metabolic research
Medchemexpress LLC Tenofovir Disoproxil | 201341-05-1 | 99.5% | 519.44 | 100 MG
Tenofovir Disoproxil is a nucleotide reverse transcriptase inhibitor. It is used to treat HIV and chronic Hepatitis B, and is intended for research use only.
- Nucleotide reverse transcriptase inhibitor
- Used to treat HIV
- Used to treat chronic Hepatitis B
- Solid appearance
- White to off-white color
- Purity 99.5%
- For research use only
Apexbio Technology LLC Oprozomib (ONX-0912) 935888-69-0 25mg
Oprozomib (ONX-0912 CAS 935888-69-0) is an orally bioavailable small-molecule inhibitor of the proteasome structurally related to carfilzomib It targets predominantly the chymotrypsin-like proteolytic activity of the proteasome inducing apoptosis and growth inhibition in multiple myeloma (MM) cell lines including those resistant to bortezomib In preclinical models oprozomib activates pro-apoptotic pathways involving caspases-3 -8 -9 as well as PARP cleavage suppresses angiogenesis and tumor cell migration thereby reducing tumor progression and prolonging survival Its biological activity positions oprozomib as a promising compound for MM research
Apexbio Technology LLC Palbociclib (PD0332991) Isethionate, 10mg. Cas: 827022-33-3 MFCD: MFCD22666589. CDK4/6 inhibitor,highly selective
CDK4/6 inhibitor,highly selective 827022-33-3. MFCD22666589
Medchemexpress LLC 3-(7-fluoro-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione | 2359705-88-5 | MFCD31556181 | 99.9% | 262.24 g·mol⁻¹ | C13H11FN2O3 | 25 MG
Lenalidomide-F is a cereblon-binding E3 ligase ligand used as the recruiting moiety in PROTAC degraders targeting FLT3. It promotes ubiquitination and proteasome-dependent degradation of FLT3 in cellular studies, supporting degrader development and mechanism-of-action experiments.
- E3 ligase ligand that binds cereblon.
- Facilitates targeted FLT3 degradation via the ubiquitin-proteasome pathway.
- High purity suitable for biochemical and cellular assays.
- Stable solid with multiyear room-temperature storage.
- Available in multiple small-scale packaging sizes for research use.
- Molecular weight 262.24 g·mol⁻¹; formula C13H11FN2O3.
Medchemexpress LLC Insulin (human), 21A-glycine-30Ba-L-arginine-30Bb-L-arginine- | 160337-95-1 | ≥95.0% | 6062.89 | 50 MG
Insulin glargine is a long-acting insulin analog that lowers blood sugar and can be used in diabetes research. High doses of Insulin glargine may also promote the proliferation of bladder cancer cells.
- Long-acting insulin analog
- Lowers blood sugar
- Promotes proliferation of bladder cancer cells at high doses
Medchemexpress LLC Felodipine | 72509-76-3 | 99.83% | 50 MG
Felodipine is a dihydropyridine, a potent and vasoselective calcium channel antagonist. It effectively lowers blood pressure by targeting vascular smooth muscle, particularly in resistance vessels. This anti-hypertensive agent also possesses the ability to induce autophagy and can penetrate the blood-brain barrier.
- Potent vasoselective calcium channel antagonist
- Lowers blood pressure by acting on vascular smooth muscle
- Induces autophagy
- Able to cross the blood-brain barrier
Medchemexpress LLC Larotrectinib sulfate | 1223405-08-0 | 99.0% | 10 MG
Larotrectinib sulfate is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C).
- ATP-competitive oral inhibitor
- Selective inhibitor of TRK family receptors
- Low nanomolar inhibitory concentrations against TRKA, B, and C isoforms
Medchemexpress LLC Fostamatinib | 901119-35-5 | 99.7% | 200 MG
Fostamatinib (R788) is an oral proagent of the active compound R406. R406 is a competitive Syk/FLT3 inhibitor with a Ki of 30 nM and an IC50 of 41 nM. It also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM).
- Oral proagent of the active compound R406
- Competitive Syk/FLT3 inhibitor
- Inhibits Lyn
- Inhibits Lck
Medchemexpress LLC Fostamatinib Disodium | 1025687-58-4 | 98.3% | 200 MG
Fostamatinib Disodium is an oral prodrug of the active compound R406. It acts as an orally available and competitive Syk/FLT3 inhibitor, also demonstrating inhibitory activity against Lyn and Lck. This compound is intended for research purposes only.
- Oral prodrug of R406
- Orally available
- Competitive Syk/FLT3 inhibitor (Ki of 30 nM, IC50 of 41 nM)
- Inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM)
- Intended for research use only
Medchemexpress LLC Fostamatinib (R788) | 901119-35-5 | 99.7% | 100 MG
Fostamatinib (R788) is an oral proagent of the active compound R406. R406 is an orally available and competitive Syk/FLT3 inhibitor with a Ki of 30 nM and an IC50 of 41 nM. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM).
- Inhibits Syk and FLT3, as well as Lyn and Lck.
- Highly bioavailable and rapidly absorbed, converting completely to R406 in plasma.
- Intended for research purposes only; not for sale to patients.
Medchemexpress LLC Hydroxy Itraconazole | 112559-91-8 | 99.8% | 100 UG
Hydroxy Itraconazole is the analytical standard of Hydroxy Itraconazole, intended for research and analytical applications.
- CAS number: 112559-91-8
- Molecular weight: 721.63
- Molecular formula: C35H38Cl2N8O5
- Purity (LCMS): 99.80%
- Appearance: White to off-white solid
- Storage: 4°C, protect from light (solid); -80°C, 6 months; -20°C, 1 month (in solvent)
- Application: Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
Medchemexpress LLC Bupropion morpholinol | 357399-43-0 | 99.7% | 10 MG
Bupropion morpholinol, also known as Hydroxy Bupropion, is a major metabolite of Bupropion. It functions by inhibiting Dopamine and Norepinephrine transporters, as well as the α4β2 nicotinic receptor in vitro. This compound plays a role in antidepressant and smoking cessation activities. It is produced from Bupropion in vivo by the genetically polymorphic enzyme CYP2B6. It inhibits [3H]norepinephrine uptake with an IC50 of 1.7 μM. This product is intended for research use only and is not sold to patients.
- Major metabolite of bupropion
- Inhibits dopamine and norepinephrine transporters
- Inhibits the α4β2 nicotinic receptor in vitro
- Contributes to antidepressant and smoking cessation activities
- Produced from bupropion by the genetically polymorphic enzyme CYP2B6 in vivo
- Inhibits [3H]norepinephrine uptake with an IC50 of 1.7 μM
- Intended for research use only
Sigma Aldrich Fine Chemicals Biosciences Purpureaglycoside A European Pharmacopoeia (EP) Reference Standard | 19855-40-4 |
Purpureaglycoside A European Pharmacopoeia (EP) Reference Standard | Mol Wt: 927.08 | 19855-40-4 |
Apexbio Technology LLC Doxazosin 74191-85-8 500mg
Doxazosin (CAS 74191-85-8) is a synthetic quinazoline derivative that functions as a selective antagonist of postsynaptic 1-adrenergic receptors By inhibiting these receptors doxazosin reduces vascular smooth muscle contraction leading to decreased peripheral resistance This pharmacological profile is valuable for research investigating 1-adrenergic signaling pathways vascular tone regulation and cardiovascular physiology Doxazosin is commonly utilized in studies related to hypertension benign prostatic hyperplasia and receptor pharmacology